Twenty-one people, including four children and six women, were killed when a minibus hit a mine in the southern Syrian town of Noa on Wednesday, the Syrian Observatory for Human Rights monitoring group said.
Opposition activists told the Observatory the minibus drove over a mine planted by forces loyal to President Bashar al-Assad. There was no immediate comment from the government.
The explosion was reported in rebel-held territory in Deraa province but there are also army troops in the nearby base of Tel al-Jumaa, which is besieged.
Assad's forces are battling an uprising that grew out of protests against his family's four-decade grip on the country.
Violence has continued in recent days despite pleas from Arab and Muslim organisations for a ceasefire to mark the Muslim festival of Eid al-Adha.
The British-based Observatory, which is opposed to Assad, reported clashes in most provinces on Wednesday and said warplanes had been deployed to the eastern desert city of Deir al-Zor.
The group said at least 27 government soldiers had been killed during intense clashes in Deir al-Zor over the past two days although rebels gave a figure more than double that.
Pro- and anti-government militias have fragmented the country into fiefdoms, with hardline Islamist rebels fighting Kurds and other opposition groups.
The Observatory reported that 29 jihadist fighters, some from the al Qaeda-linked Islamic State of Iraq and the Levant, and 12 Kurdish militants were killed during clashes on Tuesday in the northeast province of Hasaka.
It is increasingly difficult for international aid workers to operate in the lawless rebel-held northern provinces.
Six Red Cross workers and a colleague from the Syrian Arab Red Crescent were abducted on Sunday after delivering medical supplies in the northern province of Idlib. Four were released the next day.
Aid workers say the Damascus government has also placed barriers on working in Syria such as rejecting visas or preventing convoys from entering certain areas.
Syrians complain aid is not getting through to many areas of the country, especially to residents living in rebel-held territory who say the government is restricting access.
ICRC spokesman Ewan Watson said that his group was asking "all authorities for access" to the besieged town of Mouadamiya southwest of Damascus, where he estimated 10,000 civilians were trapped.
"We are concerned about the situation in the besieged town of Mouadamiya, under siege for 10 months. We have not been able to enter and suspect there are medical care needs and possibly of essential aid like food and water," he said in Geneva.
Reuters
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